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| Interleukin-17 | |
| OP-006 Intra-articular Interleukin-17 Overexpression in the Knee Joint of Collagen Type II Immunized Mice Accelerates the Onset and Aggravated Joint Destruction. E Lubberts, L Joosten, L van de Bersseiaar, F van de Loo, P Schwarzenberger, W van den Berg. University Hospital Nijmegen, The Netherlands and Louisiana State University Medical Center, New Orleans, LA. IL-17 is a T cell derived cytokine that is proinflammatory and promotes osteoclastogenesis. In this study, Lubberts et al introduced IL-17, via a recombinant adenoviral vector as a single injection, into the knee joint of mice with collagen-induced arthritis (CIA) to investigate the in vivo effects of IL-17. Results: Expression of the transgene, IL-17, was confirmed both in the infiltrate and the exudates of the knee joint, as well as in the ipsilateral paw. This overexpression of IL-17 during the early phase of CIA was associated with an earlier onset of arthritis, enhanced synovial inflammation, and earlier radiographic joint damage compared with control mice with CIA who received replication-deficient adenoviral vector. Interestingly, IL-17 overexpression in the knee was associated with more severe arthritis in the ipsilateral paw. Blocking IL-1a/b, by specific antibodies, had no effect on the severity of arthritis in the injected knee joint. Editorial Comment: These data indicate that IL-17 overexpression promotes established arthritis and that IL-17 induced inflammation appears to be independent of IL-1. These data do not clarify whether introduction of IL-17 into normal mice causes arthritis. | |
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