Leflunomide
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Dear Sir, Does Leflunomide increase the suceptibility to infection to tuberculosis? Should it be used in persons having chronic infections like Tuberculosis? Thanks |
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In the RA patient population, we have not seen an increase incidence of TB with leflunomide or methotrexate. Thus most rheumatologists do not screen for latent TB with a PPD prior to starting one of those agents-- unlike with starting a TNF agent (Enbrel, Humira, Remicade), in which PPD is mandatory. however ir remains a theoretical risk and thus treatment for latent TB should be considered in patients who are PPD positive. |
Last update: 03:17 PM Monday, April 9, 2007
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Alan Matsumoto, M.D.
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