Clinical Trials
Rheumatoid
Arthritis Trials
at Johns Hopkins Arthritis Center at Bayview
Osteoarthritis
Trials
at Johns Hopkins Arthritis Center at Bayview
Genetics Study
at your local clinic or doctor's office
Fibromyalgia
Trials
at Johns Hopkins Arthritis Center at Bayview
Psoriatic Arthritis Trials
at Johns Hopkins Arthritis Center at Bayview
Ankylosing Spondylitis Trials
at Johns Hopkins Arthritis Center at Bayview
Frequently Asked Questions about Clinical Trials
Learn the benefits and risks of participating in a clinical trial
IFPMA Clinical Trials Portal
A service of the International Federation of Pharmaceutical Manufacturers & Associations
ClinicalTrials.gov
A service of the National Institutes of Health
Center Watch
A clinical trials listing service
Trial #1 - posted 3/06/08
Title: A Randomized, Double-Blind, Parallel Group, International Study to Evaluate the Safety and Efficacy of Ocrelizumab Compared to Placebo in Patients with Active Rheumatoid Arthritis Who Have an Inadequate Response to at Least One Anti-TNF-α therapy
Purpose: To determine the safety and effectiveness of ocrelizumab versus placebo in reducing the signs and symptoms of rheumatoid arthritis (RA) when used in combination with methotrexate or Arava™ either alone or in combination with other non-biologic DMARDs in patients with active RA who have an inadequate response to at least one anti-TNF-α therapy
Recruiting Patients:
- Men and women > 18 years of age with active rheumatoid arthritis with current use of methotrexate or leflunomide (Arava™)
Additional Info: This is a 96 week study that will involve a 48 week double-blind treatment period and a 48 week study extension period.
| Coordinator/Contact: | Marilyn C. Towns (410) 550-0579 |
| Principal Investigator: | Clifton O. Bingham, III, M.D. |
| IRB#: | NA_00010839 |
Trial #2 - posted 3/06/08
Title: A mechanism of action study to evaluate the effects of IL-6 receptor blockade with tocilizumab (TCZ) on lipids, arterial stiffness, and markers of atherogenic risk in patients with moderate to severe active rheumatoid arthritis.
Purpose: To determine the safety and effectiveness of tocilizumab versus placebo in reducing the signs and symptoms of rheumatoid arthritis (RA) when used in combination with methotrexate and to also determine if a reduction in the signs and symptoms of RA also decreases cardiovascular risk.
Recruiting Patients:
- Men and women 18–75 years of age with active rheumatoid arthritis with current use of methotrexate.
Additional Info: This is a 104 week study that will involve a 24 week double-blind treatment period and an 80 week study extension period.
| Coordinator/Contact: | Marilyn C. Towns (410) 550-0579 |
| Principal Investigator: | Jon T. Giles, M.D. |
| IRB#: | NA_00013387 |
Trial #3 - posted 5/19/05 (updated 1/25/07)
Title:Yoga and Arthritis Research Study
Purpose of Study: Yoga is an ancient and enjoyable form of physical activity that improves strength, balance, flexibility, stress management and relaxation. We want to learn if people with arthritis may benefit from yoga.
Recruiting patients:
- with arthritis(OA) in knee(s) or inflammatory arthritis (RA)
Additional Information:
- Yoga classes are held 2 times a week for 8 weeks at the JH Bayview Fitness Center
- Classes have been specifically designed for people with arthritis and are taught by an experienced Yoga teacher
| Coordinator/Contact: | Steffany Haaz (410) 550-5216 email: shaaz1@jhem.jhmi.edu |
| Principal Investigator: | Susan Bartlett, Ph.D. |
| IRB#: | HBV05-01-24-09 |
Trial #1 - posted 1/24/04
Title: Osteoarthritis Initiative (OAI): A Knee Health Study
Purpose of Study: The OAI is a nationwide research study sponsored by the National Institutes of Health that will help us better understand how to prevent and treat knee osteoarthritis.
Recruiting patients:
- Men and women who are 45 to 79 years old and have one or more of the following:
- overweight
- hand osteoarthritis (knobby fingers)
- knee pain during the past year (however, you don't have to have current knee pain to join)
- previous knee injury
*This study is not for those who have rheumatoid arthritis, joint replacements in both knees, are unable to walk without assistance or can't have a knee MRI.
Contact: |
(410) 706-5791 or |
For more details about this study, please visit the OAI website, print a copy of the Maryland OAI brochure and read our OAI news story |
|
Trial #2 - posted 5/19/05 (updated 1/25/07)
Title:Yoga and Arthritis Research Study
Purpose of Study: Yoga is an ancient and enjoyable form of physical activity that improves strength, balance, flexibility, stress management and relaxation. We want to learn if people with arthritis may benefit from yoga.
Recruiting patients:
- with arthritis(OA) in knee(s) or inflammatory arthritis (RA)
Additional Information:
- Yoga classes are held 2 times a week for 8 weeks at the JH Bayview Fitness Center
- Classes have been specifically designed for people with arthritis and are taught by an experienced Yoga teacher
| Coordinator/Contact: | Steffany Haaz (410) 550-5216 email: shaaz1@jhem.jhmi.edu |
| Principal Investigator: | Susan Bartlett, Ph.D. |
| IRB#: | HBV05-01-24-09 |
Trial #3 - posted 10/26/2007
Title: A Multi-Center, Randomized, Double-Blind Comparison of 4 Dose Regimens of PLA-695, Naproxen, and Placebo Administered Daily for 6 Weeks in Subjects with Active Osteoarthritis of the Knee.
Purpose of Study: The purpose of this study is to evaluate the overall safety of the research study drug PLA-695 compared with naproxen in patients with osteoarthritis of the knee.
Recruiting patients:
- Diagnosed with osteoarthritis of the knee
- Men and women ages 50-75
| Coordinator/Contact: | Marilyn Towns 410-550-0579 email: mctowns@jhmi.edu |
| Principal Investigator: | Clifton O. Bingham, M.D. |
| IRB#: | NA_00006541 |
Trial #1 - posted 1/16/04
Title: Multiple Autoimmune Disease Genetics Consortium (MADGC)
Purpose of Study: The Multiple Autoimmune Disease Genetics Consortium (MADGC) is a group of genetic researchers who have joined efforts to identify and understand the genes that autoimmune diseases have in common. If at least 2 members of your family are affected with different autoimmune diseases from the below list, your family may qualify to participate in this important research study.
- Multiple Sclerosis
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Systemic Lupus
- Type I Diabetes
- Ulcerative Colitis or Crohn’s Disease
- Psoriasis
- Autoimmune Thyroid Disease
- Sjogren’s Syndrome
Participation includes a brief telephone interview and providing a blood sample, which can be drawn at your local clinic or MD’s office.
To learn more about this NIH funded study, visit our website at http://www.madgc.org or call toll-free to either of these consortium members:
EAST: North Shore University Hospital
Manhasset, NY 1-877-698-9467
or
WEST: University of Minnesota
Minneapolis, MN 1-888-226-8636
Principal Investigator: |
Dr. Timothy Behrens |
IRB®#: |
0003M43141 |
Trial #1 - posted 1/25/07
Title: Lifestyle Physical Activity for Fibromyalgia
Purpose of this study: To find out if increasing physical activity reduces pain and symptoms in adults with Fibromyalgia.
Recruiting Patients: Adults with Fibromyalgia between the ages of 18-65, who are generally healthy and physically inactive.
Coordinator/Contact: |
Lora Schmidl 410-550-8248 |
Principal Investigator: |
Kevin Fontaine PhD |
IRB®#: |
NA_00003328 |
Trial #1 - posted 2/21/07
Title: Psoriatic Arthritis Research Study
Purpose of this study: To determine if autoantibodies exist in patients with psoriatic arthritis.
Recruiting Patients: Patients with a clinical diagnosis of psoriatic arthritis and active skin lesions are eligible for participation.
The study requires one clinic visit during which the participant will be asked to provide two tubes of blood and undergo a skin biopsy. The blood will then be analyzed for the presence of autoantibodies and the skin will be used as a possible source of antigen.
You will receive $50.00 and a parking coupon for your participation.
Coordinator/Contact: |
Tasha Rice 410-955-1120 |
Principal Investigator: |
Dr. John Flynn |
IRB®#: |
03-11-20-02 |
Trial #1 - posted 2/21/07
Title: Arthritis Research Study for Ankylosing Spondylitis Patients
Purpose of this study: To develop a measure of spinal fusion that is capable of detecting changes in the degree of fusion, over 1 year in patients with Ankylosing Spondylitis.
Recruiting Patients: Eligibility Criteria
- Must be age 18 years or older
- Onset of AS at age 17 or older
- Not currently taking or planning to receive treatment with anti-TNF alpha medications (etanercept, infleximab, adalimumab) for 1 year.
- Must not have complete fusion of the spine.
- Must be able to travel to the National Institutes of Health
Coordinator/Contact: |
Tasha Rice 410-955-1120 |
Principal Investigator: |
Dr. John Flynn |
IRB®#: |
04-08-09-05 |